Diuretic Response in Acute Heart Failure
Diuretic Response in Acute Heart Failure
In this retrospective study, we present a novel measure for diuretic response in acute HF—weight loss indexed to diuretic use. This metric yielded at least equivalent prognostic information compared with its component parts, while providing a more easily interpreted signal for patient response to diuretics. Further research will be needed to confirm our findings. In this study, patients with a poor diuretic response had more advanced HF, worse renal function and were more likely to have a history of atherosclerosis and diabetes. Poor diuretic response was strongly and independently associated with less dyspnoea relief and an increased incidence of in-hospital worsening HF, as well as post-discharge mortality and rehospitalization for HF. Early identification of subjects with impaired diuretic response may open doors towards patient-tailored treatment strategies.
Conclusion
In this retrospective study, we present a novel measure for diuretic response in acute HF—weight loss indexed to diuretic use. This metric yielded at least equivalent prognostic information compared with its component parts, while providing a more easily interpreted signal for patient response to diuretics. Further research will be needed to confirm our findings. In this study, patients with a poor diuretic response had more advanced HF, worse renal function and were more likely to have a history of atherosclerosis and diabetes. Poor diuretic response was strongly and independently associated with less dyspnoea relief and an increased incidence of in-hospital worsening HF, as well as post-discharge mortality and rehospitalization for HF. Early identification of subjects with impaired diuretic response may open doors towards patient-tailored treatment strategies.
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